Academy of Finland  
Funding decision
Organisation University of Turku
Project title Radiopharmaceuticals for pretargeted PET imaging beyond the barriers (PET Barrier)
Applicant / Contact person Airaksinen, Anu
Decision No. 343608
Decision date 03.06.2021
Funding period 01.09.2021 - 31.08.2025
Funding 600 000
Project description
Positron emission tomography (PET) is an essential method in clinical diagnostics and in drug discovery and development. Nanomedicines and antibody-based therapies are emerging technologies in drug development for treating cancer and neurodegenerative diseases. Nanomedicines and antibodies have typically slow pharmacokinetics, which necessitates use of long living radioisotopes for tracing their distribution with PET. This causes unnecessary radiation burden. The main objective of the project is to develop PET radiopharmaceuticals, which allow pretargeted PET imaging of nanomedicines and antibodies by using short living positron emitters and with lower radiation dose. The developed diagnostics methods will advance development of therapies against cancer and neurodegenerative diseases and can later be utilized in patient stratification for identifying the patients that are most likely to benefit from the therapy.