Academy of Finland  
Funding decision
Organisation University of Helsinki
Project title Deciphering the structure-property relationships of the hydrophilic corona and drug loading in drug delivery systems on their interactions with biological systems
Applicant / Contact person Luxenhofer, Robert
Decision No. 342983
Decision date 03.06.2021
Funding period 01.09.2021 - 31.08.2025
Funding 497 416
Project description
Nanomedicine utilizes nanotechnology for the development of better medicines, vaccines and diagnostic tools and has helped many patients in the last decade to have a better quality of life. Nanoscopic polymer micelles that spontaneously form from amphiphilic block copolymers are one main material class in nanomedicine for drug delivery and have great relevance for the solubilization of hydrophobic drugs, which is one of the great challenges in pharmaceutical technology. The present proposal will probe and decipher the relationships between drugs and polymers on the one hand and complex biorelevant media on the other hand. This will show how the polymer structure affects important processes in our body. These results will be correlated with evaluations of bioavailability and pharmacokinetics. Our results will greatly benefit our understanding of these fundamental relationships and will enable the design of improved nanomedicines in the future.