Academy of Finland  
Funding decision
Organisation University of Helsinki
Project title Molecular basis of energy transduction in mitochondrial respiratory complex I
Applicant / Contact person Sharma, Vivek
Decision No. 338176
Decision date 03.06.2021
Funding period 01.09.2021 - 31.08.2025
Funding 494 680
Project description
Energy in the form of ATP is produced in the mitochondria of the cell by a complex interplay of charged particles. Despite decades of research efforts, it is not fully understood how it is accomplished, and how diseases are related to malfunction in this process. In this project, we will study one of the most complicated proteins, mitochondrial respiratory complex I, which is central to ATP production. By applying computer modeling and simulations on high-performance supercomputers, we will learn how complex I functions, and how its function breaks down due to disease-causing mutations. Our work will enhance understanding of one of the most fundamental processes in biology that is energy production.