Finlands Akademi  
Sökande / Kontakt person Oresic, Matej
Organisation Åbo universitet
Projektets titel Human exposure to per- and poly-fluoroalkyl substances – role of the gut microbiome and bile acid metabolism in mediating impact (PFASgut)
Beslutnr 333981
Beslutsdatum 27.05.2020
Finansierings period 01.09.2020 - 30.08.2024
Finansiering 500 941
Beskrivning av projektet
The theme of the proposed project is the assessment of the health impacts of exposure to per- and poly-fluoroalkyl substances (PFAS), and the elucidation of the effects of such exposure on both the gut microbiome and bile acid metabolism. Based on the preliminary data by us and others, we hypothesise that this interplay may impact lipid metabolism and human health. The project combines expertise in systems biology, metabolomics and comprehensive chemical analyses. Instead of merely screening for exposure levels of environmental chemicals, we will identify effect-based markers of exposure that anchor the exposures to actual health outcomes at the individual level. This highly-interdisciplinary project has the potential to open new areas of investigation related to the study of the impact of chronic chemical exposures on human health and for more relevant, accurate chemical safety assessment.