Finlands Akademi  
Sökande / Kontakt person Lindahl, Maria
Organisation Helsingfors universitet
Projektets titel Exploration of the mode of action and beta-cell regenerating effect of ER stress regulating MANF in mouse diabetes models
Beslutnr 333974
Beslutsdatum 27.05.2020
Finansierings period 01.09.2020 - 31.08.2024
Finansiering 499 957
Beskrivning av projektet
Diabetes mellitus (DM) is characterized by hyperglycemia caused by the inability of pancreatic beta- cells to maintain sufficient levels of circulating insulin. T1 diabetes (T1D) is caused by autoimmune destruction of beta-cells whereas insulin resistance and progressive beta-cell death characterizes T2D. About 425 million people have DM and its incidence is increasing rapidly. The current medications alleviate symptoms but cannot prevent devastating vascular complications of DM. Thus, one strategy for improving DM therapies is to define and validate novel approaches to protect beta-cells and activate their regeneration. We have found that mesencephalic astrocyte-derived neurotrophic factor (MANF) is needed for the survival and proliferation of beta-cells in mice and has a regenerative effect on human and mouse beta-cells in culture. Our main objectives are to elucidate the mode of MANF action in beta-cells and to evaluate the therapeutic potential for MANF in mouse models of DM.