Finlands Akademi  
Sökande / Kontakt person Palvimo, Jorma
Organisation Östra Finlands universitet
Projektets titel SUMOylation-regulated chromatin protein networks in transcription factor-directed cellular differentiation
Beslutnr 333866
Beslutsdatum 27.05.2020
Finansierings period 01.09.2020 - 31.08.2024
Finansiering 490 510
Beskrivning av projektet
The project investigates how SUMOylation, covalent modification of proteins, regulates chromatin protein networks during cellular differentiation and reprogramming and in the maintenance of cell phenotype. The plasticity of cell phenotypes will be studied using genome-wide and proteome-wide approaches in cell differentiation and reprogramming models. The aim is to identify SUMOylation-regulated interactions on chromatin and to determine how SUMOylation-dependent regulatory mechanisms influence the formation of genomic contacts and the function of key transcription factors directing gene programs during cell differentiation. The project will also investigate the role of SUMOylation on the chromatin and in the function of the glucocorticoid receptor (GR) in leukemia cells, particularly in the context of glucocorticoid resistance. The results of this study provide new insights into the mechanisms of cancer formation, advance new epigenetic combination therapies and regenerative medicine.