Finlands Akademi  
Sökande / Kontakt person Granberg, Kirsi Johanna
Organisation Tammerfors universitet
Projektets titel Dissecting immunosuppression in brain tumor tissue
Beslutnr 333545
Beslutsdatum 27.05.2020
Finansierings period 01.09.2020 - 31.08.2022
Finansiering 250 000
Beskrivning av projektet
Immunotherapy is associated with efficient and long-lasting treatment responses in several cancers, but only a subpopulation of patients respond to current approaches. Partly because of this, it is important to further stratify the patients based on their predicted immune response. In the project, we will categorize patients based on the type of immunosuppression in tumor microenvironment and investigate which regulators drive tumor-induced immunosuppression in brain tumors. Computing, analysis of large-scale measurement data, wet-lab experimentation, and patient-derived brain tumor material will be used. The obtained results aim to clarify which treatment options could work the best for each patient. The project can also lead to the identification of novel treatment targets for personalized immunotherapy.