Finlands Akademi  
Sökande / Kontakt person Kaarniranta, Kai
Organisation Östra Finlands universitet
Projektets titel Autophagy as a therapy target in age-related macular degenration
Beslutnr 333302
Beslutsdatum 27.05.2020
Finansierings period 01.09.2020 - 31.08.2024
Finansiering 500 000
Beskrivning av projektet
AMD is the most common cause of visual impairment in the Western world. AMD is a storage disease in which harmful protein accumulations develop behind the retina. For the first time ever, our recent study showed that AMD is associated with impaired autophagy, which is an important clean-up mechanism of the fundus of the eye. The study can be regarded as a breakthrough, as the results change our understanding of the pathogenesis of AMD and also open new avenues for the treatment of AMD. In this project, we study autophagy mechanims in AMD clinical material, animal models and stem cell cultures. We try to find novel treatments to AMD targeted to autophagy. The research project is done in University of Eastern Finland in ophthalmology group leaded by professor Kai Kaarniranta