Finlands Akademi  
Sökande / Kontakt person Hanski, Leena
Organisation Helsingfors universitet
Projektets titel Tracking the untrackable: polypharmacology and biomarkers on persistent Chlamydia pneumoniae infections
Beslutnr 333291
Beslutsdatum 27.05.2020
Finansierings period 01.09.2020 - 31.08.2024
Finansiering 494 877
Beskrivning av projektet
Persistent infections caused by Chlamydia pneumoniae have been identified as risk factors for various chronic diseases, but effective measures for diagnosing or eradicating them are missing. The aim of this project is to develop new treatment strategies on these infections based on multi-target drugs, as well as to identify biomarkers suitable for fast and convenient identification of the condition. The studies on novel treatments include target deconvolution of newly identified agents sensitizing the infection to antibiotics, drug repositioning and investigating probiotics for rising innate responses against the infection. Biomarker studies include characterization of infection-induced extracellular vesicles and studies on a chlamydial enzyme cleaving human proteins. The obtained results will improve our understanding on the complex interactions of C. pneumoniae and its host and may be translated into remarkable health benefits.