Finlands Akademi  
Sökande / Kontakt person Hennah, William
Organisation Helsingfors universitet
Projektets titel Genetic Testing in Pediatric Neuropsychiatric Disorders
Beslutnr 332583
Beslutsdatum 27.05.2020
Finansierings period 01.09.2020 - 31.08.2024
Finansiering 450 000
Beskrivning av projektet
Genetic understanding of psychiatric disorders has greatly advanced, leading to calls for this information to be taken to the clinic. We are performing genome analysis in patients with childhood neuropsychiatric disorders, where large impact de novo mutations are more common, in order to see if genetic testing is a useful tool for the clinic. Furthermore, the underlying symptoms in these disorders can vary over time, but it is not possible to predict which children or what symptoms will improve, meaning that treatment and rehabilitation are given on the current presentation of symptoms. Any single genetic variation is neither necessary nor sufficient in the etiology of these disorders and symptoms. Thus, we are also longitudinally collecting a multitude of different levels of biological data that can vary with time, in order to identify potential biomarkers that could be used to better predict disorder progression and outcome, so that treatment and rehabilitation can be personalized.