Finlands Akademi  
Sökande / Kontakt person Goffart, Steffi
Organisation Östra Finlands universitet
Projektets titel The start and end of a circle - Solving the mitochondrial DNA replication initiation and termination mechanisms (MitoRepIT)
Beslutnr 332458
Beslutsdatum 27.05.2020
Finansierings period 01.09.2020 - 31.08.2024
Finansiering 544 915
Beskrivning av projektet
Mitochondria, the energy-producing organelles in our cells, have their own small genome, mtDNA. This mtDNA is important for the proper function of our body, and accumulating damage to the mtDNA molecules of our cells might be one cause of ageing and age-related diseases such as Alzheimer’s Parkinson’s or cancer. MtDNA is constantly duplicated to ensure that each cell contains a sufficient amount of intact copies, but this replication is only poorly understood. In this project we will analyze the mechanisms working at the beginning and end of mtDNA replication and the factors regulating these processes. We will find out how these processes adapt to problems and whether they contribute to the damage of mtDNA.