Finlands Akademi  
Sökande / Kontakt person Lahesmaa, Riitta Liisa Maria
Organisation Åbo universitet
Projektets titel New regulators of human regulatory T cell differentiation and function
Beslutnr 331793
Beslutsdatum 27.05.2020
Finansierings period 01.09.2020 - 31.08.2024
Finansiering 547 331
Beskrivning av projektet
The central role of the immune system is to attack intruders such as pathogens or cancer cells, but not own normal cells and tissues. To achieve this, tight regulation by T-cells specialized to distinguish self from non-self structures is critical. The role of regulatory T-cells is to keep harmful immune reactions to host in control and their aberrant function results in immune diseases and cancer. We will study the molecular mechanisms through which the new factors we have identified influence the function of the regulatory T-cells. We expect the results to improve understanding of immune regulation and molecular mechanisms of immune mediated disorders.