Finlands Akademi  
Sökande / Kontakt person Vihinen-Ranta, Maija
Organisation Jyväskylä universitet
Projektets titel Way out through chromatin: nuclear exit of herpesvirus capsids and mRNA
Beslutnr 330896
Beslutsdatum 27.05.2020
Finansierings period 01.09.2020 - 31.08.2024
Finansiering 548 195
Beskrivning av projektet
The understanding of intranuclear virus dynamics is essential for basic research and for the development of oncolytic virus therapy and novel antivirals that aim to block the viral life cycle. The general goal of this project is to unravel the mechanisms of virus-induced chromatin reorganization. The specific objectives are to determine the mechanisms of virus protein-induced alterations of the chromatin architecture, and to study the dynamics of viral mRNA and capsids within the chromatin network. Our research utilizes a new interdisciplinary approach combining biology and biophysics with cutting-edge techniques of imaging, advanced image analysis, and biophysical modeling.