Finlands Akademi  
Sökande / Kontakt person Siljander, Pia R-M
Organisation Helsingfors universitet
Projektets titel Curing the non-healing wound: Platelet extracellular vesicle (EV) mechanisms and theranostic opportunities in cancer (PLEASER)
Beslutnr 330486
Beslutsdatum 27.05.2020
Finansierings period 01.09.2020 - 31.08.2024
Finansiering 534 589
Beskrivning av projektet
Blood platelets regulate wound healing, but increasing evidence suggest that paradoxically, platelets also support tumor growth and metastasis. In this project, we will find out how platelets and cancer cells exchange information via extracellular vesicles (EVs), with the hypothesis that tumor cells and their EVs activate and reprogram platelets into promoting cancer progression and metastasis. Analysis of the composition of the released EVs from the tumor-educated platelets and elucidating the affected signaling pathways in the cancer cells will provide both insight into how a tumor hijacks platelet functions, and candidates for biomarkers which will be searched from the blood of cancer patients. How tumor-educated EVs compared to normal platelet EVs are preferably taken up by cancer cells will provide candidates for novel drug delivery systems. In all, this novel angle to cancer progression will provide improved insight and innovative weapons to help fight cancer.