Academy of Finland  
Funding decision
Applicant / Contact person Laaksonen, Timo
Organisation Tampere University
Project title Triplet-triplet annihilation upconversion for localized photochemical reactions and therapies
Decision No. 326429
Decision date 18.06.2018
Funding period 01.01.2019 - 31.08.2022
Funding 534 740
Project description
Light-based therapies are an attractive solution to target disease sites as they enable a better control of targeting and can reduce many harmful side effects of conventional therapies. The main drawback is that it is usually limited to using red or near-IR light, as all visible light below 600 nm is efficiently absorbed by tissue. Triplet-triplet annihilation (TTA) molecule pairs can be loaded into liposomes for the localized generation of blue light. The unique feature of the TTA process is that it will convert light from a longer well-penetrating wavelength to a shorter wavelength when the molecules are co-localized. Further, these compounds can be loaded into liposomes, which are ideal carriers for a range of drug release applications. The liposomes can carry the lipophilic TTA pairs within their lipid bilayer and the drug cargo in their core. Red light can then be used to penetrate tissue and locally generate the emission needed. These carriers will be manufactured in the project.