Finlands Akademi  
Organisation Åbo universitet
Projektets titel Bone-derived hormones (osteokines) in whole body energy metabolism
Sökande / Kontakt person Ivaska-Papaioannou, Kaisa
Beslutnr 325498
Beslutsdatum 22.05.2019
Finansierings period 01.09.2019 - 31.08.2023
Finansiering 438 434
Beskrivning av projektet
Skeleton is not only a static structural organ, but bone appears to exert also endocrine functions. Bone-derived hormones, osteokines, have been found to regulate whole body glucose homeostasis in mice. We will evaluate several putative osteokines in parallel in a carefully characterized cohort of human plasma samples and further, elucidate whether circulating osteokines can be used as surrogates for events taking place in local bone microenvironment. Osteokine expression and secretion will be evaluated in vitro in osteoblasts and adipocytes derived from mesenchymal stromal cells to pinpoint predominant origins at cellular level. If bone-derived osteokines share similar functions in humans as they do in mice, this translational project will validate the concept of bone as endocrine organ in humans. This could open new avenues for osteokines as surrogates in clinical trials which evaluate novel therapeutic strategies for bone diseases or diabetes.