Finlands Akademi  
Sökande / Kontakt person Räikkönen-Talvitie, Katri
Organisation Helsingfors universitet
Projektets titel Prenatal Origins of Mental Disorders – Glucocorticoid, Epigenomic and Genomic Mechanisms
Beslutnr 324596
Beslutsdatum 24.05.2019
Finansierings period 01.01.2020 - 31.08.2023
Finansiering 440 000
Beskrivning av projektet
Exposure to environmental adversity in utero can have lifelong consequences on vulnerability to mental disorders. During fetal development, rapid growth and plasticity of the brain and the entire nervous system render them sensitive to the effects of environmental factors. These effects can confer adaptive advantages or lasting vulnerabilities, a developmental plasticity phenomenon called programming. Evidence shows that prematurity and small body size at birth, studied extensively as proxies of intrauterine programmatic effects, increase risk for a range of mental disorders with limited evidence of disorder-specificity. These studies do not, however, inform what the specific underlying intrauterine factors and biological mechanisms are. We address these critical knowledge gaps in this project.