Finlands Akademi  
Sökande / Kontakt person Saloheimo, Markku
Organisation Teknologiska forskningscentralen VTT Ab
Projektets titel Interplay between metabolism and protein secretion in saprotrophic fungi
Beslutnr 318499
Beslutsdatum 29.05.2018
Finansierings period 01.09.2018 - 31.08.2022
Finansiering 470 956
Beskrivning av projektet
The project aims at better understanding of the adaptation of the cells to conditions in which secreted proteins are produced in large quantities, especially regarding to metabolism and transport. The main objective of the project is to identify important regulatory connections between cellular metabolism, secretory pathway and production of secreted enzymes in the saprotrophic model organism Trichoderma reesei. Novel regulatory factors will be identified in the project and their role characterized. In addition, the role of paralogous enzymes in the central carbon metabolism pathways, that respond differentially to protein production conditions, will be studied in the project.