Academy of Finland  
Funding decision
Applicant / Contact person Putaala, Jukka
Organisation Helsinki University Central Hospital
Project title Pathogenesis, prognosis, and socioeconomic impact of ischemic stroke in the young
Decision No. 318075
Decision date 30.05.2018
Funding period 01.09.2018 - 31.08.2022
Funding 240 566
Project description
Worldwide, about 1.3 million young people annually suffer an ischemic stroke at age less than 50 years, with globally increasing incidence since 1980s. These young patients are exposed to high risk of premature death, recurrent stroke, other cardiovascular events, long-term disability, incapacity for work, and need for institutional care. Although recent studies show a high prevalence of cardiovascular risk factors in young adults with stroke, in up to half the stroke mechanism remains elusive (cryptogenic). Studies also suggest that many patients have silent cerebrovascular pathologies. We aim to address 5 main study questions in young patients with ischemic stroke: (1) Strength of association of cardiovascular risk factors; (2) Adherence to secondary prevention medication; (3) Vocational, social, and economic consequences; (4) Precipitants and progress of silent cerebrovascular disease over time; and (5) Risk factors and pathogenic mechanisms leading to cryptogenic strokes.