Finlands Akademi  
Sökande / Kontakt person Vilkki, Johanna
Organisation Naturresursinstitutet
Projektets titel Resolving genomic features related to immunological response to improve functional annotation of the bovine genome and produce tools for enhancing disease resistance in livestock
Beslutnr 317998
Beslutsdatum 29.05.2018
Finansierings period 01.09.2018 - 31.08.2022
Finansiering 522 549
Beskrivning av projektet
The objective of the project is to characterize the genetic, molecular, and physiological mechanisms which underpin bovine immunological response (resistance to mastitis) using an array of -omics approaches in a challenge study with two pathogens in cultured mammary epithelial cells combined with information from association studies with phenotypic breeding value estimates and information from the whole genome sequence. The project aims at improving the functional annotation of the bovine genome as part of the international FAANG consortium. We will be the first group to provide information on genomic features related to host cell responses to specific pathogens. The research is expected to provide tools for selection of animals better adapted to environmental challenges emerging with climate change (new pathogens) and for improved production, healthier animals and possibilities to reduce the use of antibiotics in animal production.