Finlands Akademi  
Sökande / Kontakt person Jolkkonen, Jukka
Organisation Östra Finlands universitet
Projektets titel Human glial chimeric mice - a novel toll to understand functional stroke recovery
Beslutnr 317866
Beslutsdatum 03.05.2018
Finansierings period 01.09.2018 - 31.12.2020
Finansiering 250 000
Beskrivning av projektet
Stroke is one of leading causes of adult disability causing a huge burden on patients, relatives and health care. Therapeutic options are limited, but a lot of hope is placed on restorative therapies. The aim of the present project is to advance our understanding of human astrocytes in brain repair and plasticity after cerebral ischemia. We have an unique access to human glial chimeric mice, which allow studies on spontaneous recovery and contribution of human brain diseases to recovery process. Molecular profiling is expected to reveal novel targets for development of restorative therapies.