Finlands Akademi  
Sökande / Kontakt person Korpi, Esa
Organisation Helsingfors universitet
Projektets titel Midbrain inhibition regulating motivation and emotions
Beslutnr 317399
Beslutsdatum 03.05.2018
Finansierings period 01.09.2018 - 31.08.2022
Finansiering 450 000
Beskrivning av projektet
Midbrain inhibition regulating motivation and emotions. Brain diseases produce enormous harm to the persons affected, their families and the society. We are studying subpopulations of inhibitory neurons located in the midbrain, where these neurons participate in predicting consequences of future actions. Dysregulation of these functions related to motivation is essential in addiction, depression and anxiety. Using modern neurobiological techniques, we can analyze how selective activation or inactivation of these neuronal subpopulations affects behavior in models of psychiatric disorders. We also use novel methods to analyze connectivity, electrophysiological properties and gene expression profiles of the midbrain neurons at a single cell level. Gene expression profiling may help to identify new molecular drug targets. Our aim is to understand better how motivation-related midbrain inhibitory neurons function and find ways to modulate their function when needed.