Finlands Akademi  
Sökande / Kontakt person Groop, Per-Henrik
Organisation Folkhälsans forskningscentrum
Projektets titel Genetic and metabolomics dissection of the pathogenesis of diabetic complications – The Finnish Diabetic Nephropathy Study (FinnDiane)
Beslutnr 316664
Beslutsdatum 03.05.2018
Finansierings period 01.09.2018 - 31.08.2022
Finansiering 450 000
Beskrivning av projektet
Diabetes is a major cause of morbidity and mortality, with one third of the patients developing diabetic kidney disease (DKD). Furthermore, diabetes is a major cause of blindness, amputations, cardiovascular disease (CVD) and strokes. This project aims to identify novel biomarkers able to identify patients at risk of DKD to allow earlier intervention to prevent - or at least to postpone – the disease. Novel causal biomarkers are desperately needed for prediction, and to guide the development of novel therapeutic targets. In addition, we aim to identify novel genetic risk factors for diabetic complication through genome-wide association studies (GWAS) and whole exome and genome sequencing. Identification of the underlying genetic factors would not only improve our understanding of the biological processes leading to DKD and other diabetic complications, but could also have translational impact as they can suggest novel biomarkers or target molecules for medical treatment.