Finlands Akademi  
Sökande / Kontakt person Hovatta, Iiris
Organisation Helsingfors universitet
Projektets titel Myelination in resilience and susceptibility to psychosocial stress-induced anxiety
Beslutnr 316282
Beslutsdatum 03.05.2018
Finansierings period 01.09.2018 - 31.08.2022
Finansiering 450 000
Beskrivning av projektet
Chronic psychosocial stress is a well-established risk factor for anxiety disorders, but the development of targets for therapeutic intervention is greatly limited by ignorance of the molecular and cellular mechanisms associated with susceptibility and resilience to these common conditions. To identify the gene-environment interactions that underline chronic psychosocial stress, we apply controlled environmental stresses to mice. We previously identified changes in the brain myelination-related gene expression and myelin thickness after chronic psychosocial stress. These findings indicate that significant modulation of white matter plasticity occurs in response to chronic stress. Our goal now is to define the molecular and cellular relationships between myelination in specific brain circuits and susceptibility and resilience to chronic stress. This project will provide a strong foundation for the rational development of novel therapeutic approaches to anxiety disorders.