Finlands Akademi  
Sökande / Kontakt person Vapalahti, Olli
Organisation Helsingfors universitet
Projektets titel Flavivirus-host interactions
Beslutnr 316264
Beslutsdatum 03.05.2018
Finansierings period 01.09.2018 - 31.08.2022
Finansiering 449 999
Beskrivning av projektet
Flaviviruses include globally important mosquito-borne dengue and zika (ZIKV) viruses, and tick-borne encephalitis virus (TBEV) endemic in Eurasia. Clinically ill patients represent a minority of these infections suggesting significant role for host factors in the outcome of the infection. We aim to discover host and viral determinants that contribute to disease severity especially in neuropathogenic TBEV and ZIKV, which are currently not well understood. The flaviviral NS1 protein has been associated with contradictory roles in the pathogenesis. Our current research suggests that changes in ZIKV NS1 protein are associated with fetal infection, as well as that ZIKV and TBEV disturb neural cell transport and differentiation. The results from host genomic studies and in vitro culture models will shed light to the molecular interactions and neuropathogenesis of ZIKV and TBEV that will aid in development of therapy and control measures.