Academy of Finland  
Funding decision
Applicant / Contact person Lahtela-Kakkonen, Maija
Organisation University of Eastern Finland
Project title Dual-targeting of BET and sirtuin proteins in cancer
Decision No. 315824
Decision date 18.06.2018
Funding period 01.09.2018 - 31.08.2022
Funding 476 598
Project description
Chemotherapy is used to treat many types of cancer. Chemotherapy has high response rates for certain tumors but it does not work well for solid tumors. Regulation of the acetylation status of chromatin core proteins, histones, is a central mechanism in epigenetic control. Disruption in the acetylation signalling plays a part in several diseases including various cancers. Regulation is controlled by mammalian Bromo and Extra Terminal (BET) family of bromodomain proteins and histone deacetylases, in which sirtuins belongs. BET family has been linked to the development of a number of extremely aggressive tumours. Sirtuins are also involved in several cancers. This project will for the first time offer a functional connection between BET proteins and sirtuins in cancer cells. In addition the dual-targeting of BETs and sirtuins will examined. It can be a promising strategy in cancer treatment and can give advantages over mono-targeting.