Finlands Akademi  
Sökande / Kontakt person Salazar-Ciudad, Isaac
Organisation Helsingfors universitet
Projektets titel How predictable is the genotype-phenotype map: combining developmental biology and quantitative genetics
Beslutnr 315740
Beslutsdatum 29.05.2018
Finansierings period 01.09.2018 - 31.08.2021
Finansiering 443 337
Beskrivning av projektet
Understanding the genotype-phenotype map or the relationship between genetic and phenotypic variation (variation in size, shape, behaviour, etc…) is a challenges of 21th century biology. By using the fly wing as an test ground, we aim to test the predictive capacity of the two main modelling approaches to the map: quantitative genetics and mathematical models of developmental biology (models about how genes interact to produce the body). We will perform artificial selection experiments on the wing morphology over generations. We will try to predict how these traits change in the next generation from these two approaches. Identifying in which situations these two approaches fail and why, should be of general and applied interest. This is because quantitative genetics is massively used, both in purely scientific questions and in applied topics such as animal and plant breeding. The other approach is likely to become more predictive as developmental systems become better studied.