Finlands Akademi  
Sökande / Kontakt person Toivola, Diana
Organisation Åbo Akademi
Projektets titel A colon-specific mouse model for colorectal cancer
Beslutnr 315139
Beslutsdatum 03.05.2018
Finansierings period 01.09.2018 - 31.08.2020
Finansiering 250 000
Beskrivning av projektet
Colon inflammation and cancer are common diseases in Finland and world-wide. Inflammation is a risk factor for colon cancer, and questions still remain regarding molecular development and treatment. Keratins are cytoskeletal stress protectors, and keratin mutationsare known risk factors for human skin and liver diseases. Their roles in intestinal disease are still unclear. Mice lacking the main keratin K8, however, develop a disease that resembles human colitis, supporting that keratins protect also in the intestine. When this model is combined with a known colon cancer mutation, the mice develop abundant tumors uniquely in the colon – similar to the human. We investigate how keratins help maintaining intestinal health and protect from diseases, and how they can be used to model intestinal inflammation and colorectal cancer. We will also start to define the role of kertatins in human intestinal diseases.