Finlands Akademi  
Sökande / Kontakt person Lindfors, Katri
Organisation Tammerfors universitet
Projektets titel Features and functions of TG3-autoantibodies in dermatitis herpetiformis
Beslutnr 314880
Beslutsdatum 03.05.2018
Finansierings period 01.01.2019 - 31.08.2022
Finansiering 450 000
Beskrivning av projektet
Dermatitis herpetiformis (DH), a.k.a. skin celiac disease (CD), is the most common extraintestinal manifestation of CD and both disorders are caused by dietary gluten in wheat rye and barley. Around 1-2% of the Western-world population suffer from CD and 10% of them have DH. DH is thought to progress from CD if CD diagnosis is delayed and the condition is left untreated but the mechanism behind this progression is obscure. The progression to DH is paralleled with epitope speading from TG2 autoantibodies to those targeting epidermal TG3. The current study will investigate the features and functions of the TG3 autoantibodies and thereby increase the understanding of DH pathogenesis and clarify the immunological mechanisms behind CD evolving to DH. The scientific impact of the project is unquestionable, but it has impact also beyond academia as new tools enabling the recognition of CD patients that are in risk of developing DH may be discovered.