Academy of Finland
Funding decision
 
Applicant / Contact person Lahesmaa, Riitta Liisa Maria
Organisation University of Turku
Project title LincRNA Orchestrated Molecular Regulatory Networks of Human Immune Response
Decision No. 329277
Decision date 03.12.2019
Funding period 01.01.2020 - 31.12.2023
Funding 455 500
WebFOCUS Report
Project description
Regulation of the immune system is critical for health: it is vital for defending us from pathogens, controlling autoimmunity and fighting cancer. T cells orchestrate the immune system and play a central role in immune response in healthy individuals. The objective of the proposed research is to gain fundamentally novel mechanistic and biologic insight into the regulation of human T cell functions and immune mediated diseases. We will focus on in-depth understanding of the role of noncoding RNA. We will combine state-of-theart computational methods, cutting-edge experimental approaches and unique human biobanks to achieve the goals. We expect to reveal new unexpected links to gene regulatory networks and mechanisms involved in immune regulation and disease pathogenesis. This in turn provides basis for developing new therapeutic and diagnostic strategies for patients suffering from autoimmune diseases.