Regulation of the immune system is critical for health: it is vital for defending us from pathogens, controlling autoimmunity and
fighting cancer. T cells orchestrate the immune system and play a central role in immune response in healthy individuals. The objective of the proposed research is to gain fundamentally novel mechanistic and biologic insight into the regulation of human T cell functions and immune mediated diseases. We will focus on in-depth understanding of the role of noncoding RNA. We will combine state-of-theart computational methods, cutting-edge experimental approaches and unique human biobanks to achieve the goals. We expect to reveal new unexpected links to gene regulatory networks and mechanisms involved in immune regulation and disease pathogenesis. This in turn provides basis for developing new therapeutic and diagnostic strategies for patients suffering from autoimmune diseases.