Academy of Finland
Funding decision
Applicant / Contact person Taipale, Jussi
Organisation University of Helsinki
Project title Defining the essential downstream targets of the Myc proto-oncogene
Decision No. 328576
Decision date 03.12.2019
Funding period 01.01.2020 - 31.12.2022
Funding 249 810
WebFOCUS Report
Project description
The transcription factor Myc is a central hub in the growth regulatory network and one the most frequently deregulated genes in cancer. Genomic studies revealed that Myc affects about 15% of all human genes, whereby many of its target genes are implicated in growth-related processes. Excess Myc activity promotes tumorigenesis, while experimental reduction of Myc levels prolongs the lifespan of flies and mice. However, due to the immense number of Myc targets it has so far been impossible to identify the critical genes for these effects. The recent invention of sophisticated genome-editing tools enables us now to address this problem in a systematic manner using the fruit fly Drosophila melanogaster as a model system for Myc-regulated growth. Transcription factors have proven to be difficult drug targets. Thus, detailed information about the essential Myc-regulated genes could aid the design of highly specific drugs for the treatment of cancer and age-related diseases.