Finlands Akademi  
Organisation Östra Finlands universitet
Projektets titel Capturing the cell state space from genomics data into models of treatment resistance in childhood leukemia
Sökande / Kontakt person Heinäniemi, Merja
Beslutnr 321550
Beslutsdatum 22.05.2019
Finansierings period 01.09.2019 - 31.08.2021
Finansiering 150 000
Beskrivning av projektet
We propose here a new concept for designing drug therapy that will attempt to avoid the emergence of resitance by monitoring how each drug affects cell states at single cell resolution. We perform the study in context of the most common childhood cancer, acute lymphoblastic leukemia. Although the overall survival has improved over past decades, 10-15% of patients still encounter relapse that leads to a dramatic increase in cytotoxic burden, which endangers the development and life-long health of children. Our goal is to find new predictive and preventive measures to avoid disease recurrence. Guided by a systems biology approach, we will carry out drug screens targeting B-cell vulnerabilities. A unique resource of primary patient samples will be utilized to study both in vivo and ex vivo treatment responses based on single cell omics and computational modeling. The results will be relevant in broader context of cancer therapy that suffers from prevalent emergence of resistance.