Academy of Finland
Funding decision
 
Name Lehtimäki, Terho
Organisation PSHP
Project title
Life-long epigenetic memory and heritability of epigenetic changes in relation to impaired glucose metabolism and the risk of type 2 diabetes and cardiovascular diseases
Decision No. 322098
Decision date 22.05.2019
Funding period 01.09.2019 - 31.08.2023
Funding 496 494
WebFOCUS Report
Project description
Epigenetic changes are reversible, respond to environmental stimuli, affect gene expression and lead to phenotype variability. We aim to increase the understanding on the mediating capacity of epigenetic changes and epigenetic stress on the long-standing accumulating cardiovascular disease and type 2 diabetes risk. We utilize the over 40 yearlong follow-up and offspring study of the Young Finns Study to investigate the stability, dynamics and heritability of DNA methylation and miRNA expression and the connections between classical risk factors and these epigenetic profiles. In addition, we aim to research the intra- and intergenerational inheritance of these epigenetic profiles, and whether they convey the risk of cardiovascular diseases to the next generation. The specific novelty and competitive edge of our study is the unique series of samples covering individuals’ lifespan from the critical phase of childhood to adulthood and extending to the next generation of their offspring.