Academy of Finland
Funding decision
Name Haapasalo, Annakaisa
Organisation UEF
Project title
Identification of pathogenic mechanisms and new biomarker and druggable candidates in frontotemporal dementia using patient-derived skin fibroblasts and neurons
Decision No. 315459
Decision date 03.05.2018
Funding period 01.09.2018 - 31.08.2022
Funding 300 000
WebFOCUS Report
Project description
Frontotemporal dementia (FTD) is an early-onset neurodegenerative disease commonly affecting individuals who still actively participate in working life. Currently, FTD cannot be cured and there are no treatments, which would affect disease progression. Nor are there specific diagnostic or prognostic biomarkers available for FTD. In the FiNeFTD project, we utilize genetically validated and well-characterized skin fibroblasts and fibroblast-derived neurons created by stem cell technology from FTD patients harboring different genetic backgrounds as well as healthy control subjects. These new patient-derived cells and clinical FTD cohort will be used to elucidate the molecular mechanisms underlying FTD pathogenesis and to screen for new candidate druggable targets and diagnostic or prognostic biomarkers.