Academy of Finland
Funding decision
Name Vainio, Seppo
Organisation OY
Project title
Wnt-mediated Kidney Tubule Induction – the Role of Secreted Extracellular Vesicles as Putative Morphogens
Decision No. 315030
Decision date 29.05.2018
Funding period 01.09.2018 - 31.08.2022
Funding 498 311
WebFOCUS Report
Project description
A new individual is formed during embryonic development and is one of the most challenging processes in nature. All living organisms form via a gradual developmental process. This process is known to depend on cell-cell and tissue interactions known as the embryonic induction (EI). The EI is a universal mechanism in nature. Here the cells exchange inductive signals. These signals commit the fate of a given cell by forming so called morphogen gradients. Such gradients define also different cell fates based on their specific amounts in a given cells in relation to the source of such inducing cells or tissues. It is typical that the EI provides specific patterning for the organs and also certain morphological structures such as is seen in the mammalian kidney. We showed earlier that the Wnt signals in the kidney EI but it remains unknown how they regulate EI. In the project, we focus to test if cell secreted extracellular vesicles serves the morphogens that remain still unknown.