Academy of Finland
Funding decision
Name Pylkäs, Katri
Organisation OY
Project title
Identification and functional characterization of novel genetic predisposing factors for breast cancer
Decision No. 307808
Decision date 17.05.2017
Funding period 01.09.2017 - 31.08.2022
Funding 434 485
WebFOCUS Report
Project description
Breast cancer is the most common malignancy in women. It is strongly influenced by hereditary risk factors, a majority of which still remains unknown. The aim of current project is to identify novel breast cancer predisposing gene defects, resolve the related disease predisposing mechanisms and if these can be targeted by drugs, and ultimately, to improve diagnostics and genetic counseling. The used approach is multidisciplinary: several next-generation sequencing based genomics and transcriptomics approaches are combined with gene editing, sophisticated biochemical assays and drug testing. Resolving the genetic susceptibility to breast cancer will improve disease risk modeling and facilitates personalized cancer screening and prevention. Improved knowledge on cancer predisposition genes and characterization of their normal and mutated versions in both normal tissues and in progression towards malignancy is expected to significantly improve cancer treatment.