Academy of Finland
Funding decision
Name Reunanen, Justus
Organisation OY
Project title
Fundamental molecular mechanisms behind microbial colonization of the human intestinal tract
Decision No. 299749
Decision date 24.05.2016
Funding period 01.09.2016 - 31.08.2021
Funding 434 485
WebFOCUS Report
Project description
Inflammatory bowel disease (IBD) has increased in since the World War II in the US and EU, and it has been estimated to reach worldwide epidemic in the coming years. IBD is characterized by chronic inflammation of the intestinal epithelium by an unknown reason. Dysbiosis of the intestinal ecosystem is a common feature in IBD, as revealed by changes in relative proportions of major phyla and genera members. The human gastrointestinal tract (GI-tract) is colonized by a multitude of microbes, called the microbiota. Our “healthy” microbiota protects us, together with our immune system, against harmful microbes by competing for nutrients and binding sites within the GI-tract. Among the key players in keeping intestinal health are the human antimicrobial peptides, which are protein antibiotics. This study explores how the microbes in health and in IBD combat our ancient immunity mechanisms, thus revealing fundamental concepts related to the generation of the bacterial repertoire within us.