Academy of Finland
Funding decision
Name Tezvergil-Mutluay, Arzu
Organisation TY
Project title
Dentin degradation: A challenge for restorative dentistry
Decision No. 296653
Decision date 27.04.2016
Funding period 01.01.2017 - 31.12.2018
Funding 106 492
WebFOCUS Report
Project description
Tooth-colored restorations have an average survival of 5.7 years due to secondary caries, caused by failure of bond integrity. About 60% of clinical dental work is replacing failing restorations, causing further damage to dentition and subsequent loss of teeth, and significant costs to the patients and society. Host-derived endogenous protease activity of dentin is mainly responsible for the progressive loss of bonding. Inhibition of this activity is a promising approach to improve the durability of restorations.The current proposal evaluated the use of curcumin, a natural polyphenol to permanently inactivate dentin collagenolytic proteases. We have successfuly shown that in a dose-dependent manner Curcuminoids can inactivate dentinal enzymatic activity. This information will eventually result in development of renewable, natural products for the clinical use to benefit the individual patient as well as the society.