Academy of Finland
Funding decision
Name Kietzmann, Thomas
Organisation OY
Project title
Cellular Compartments and New Molecules Interacting in Hypoxia-Signaling and Associated Diseases
Decision No. 296027
Decision date 27.04.2016
Funding period 01.09.2016 - 31.12.2020
Funding 500 000
WebFOCUS Report
Project description
Research within the last decade showed that hypoxia-inducible transcription factors (HIFs) play key roles in the response to low oxygen (hypoxia) and the pathogenesis of disease like diabetes, atherosclerosis, thrombosis and cancer. However, there exists diversity about the enzymes and cellular compartments participating in the regulation of HIFa stability. We found that the endoplasmic reticulum and the enzyme USP28 may be important regulators of HIFa. Therefore, the project will implement a multi- and interdisciplinary research effort focussing on: 1) the role of compartment-specific ROS generation in HIF signalling and 2) determining the functional impact of USP28 on HIFa and tumorigenesis. To do this, we will use gain and loss of function studies in cell culture and in mice and monitor ROS changes in different cellular compartments, with a new established technique. All those studies will be greatly facilitated by the expertise available in the Faculty and Biocenter Oulu.