Academy of Finland
Funding decision
Name Niskanen, Alina
Organisation OY
Project title
Inbreeding depression in nature - the genetic architecture, environment and immunity
Decision No. 295204
Decision date 24.05.2016
Funding period 01.09.2016 - 31.08.2019
Funding 261 068
WebFOCUS Report
Project description
Small populations are exposed to inbreeding that may threaten their survival via inbreeding depression, i.e. reduced individual reproductive success and survival. Inbreeding causes increased homozygosity but the exact genetic mechanisms of inbreeding depression are poorly known. In this project, I will examine the relative importance of small genome-wide effects and large local effects to inbreeding depression, and identify specific loci contributing to inbreeding depression. I will also investigate the interaction of environmental conditions and immune gene diversity with inbreeding depression. These goals will be achieved by using unique long-term data on fitness and genome-wide high-density genotypes. The results will have a profound impact on the understanding of evolutionary processes underlying decreased performance of inbred individuals. Such knowledge will help us improve both conservation schemes of endangered species and breeding plans of domesticated populations.