Academy of Finland
Funding decision
Name Hakkola, Jukka
Organisation OY
Project title
Tumareseptori PXR ravitsemuksellisessa signaloinnissa ja metabolisessa terveydessä
Decision No. 286743
Decision date 22.04.2015
Funding period 01.09.2015 - 31.08.2019
Funding 500 000
WebFOCUS Report
Project description
Type 2 diabetes has reached epidemic proportions worldwide and represents perhaps the most significant health problem of the future. Pregnane X receptor (PXR) is a newly discovered regulator of hepatic glucose and lipid metabolism. We aim to characterize role and mechanisms of PXR as a regulator of hepatic energy metabolisms with implications to whole body glucose homeostasis. To do this we aim to do systematic characterization of PXR mediated protein-protein interactions. We also test the concept that PXR downregulation could be a useful way to treat insulin resistance. These results are expected to pave the way for further drug development involving PXR pathway.