Academy of Finland
Funding decision
Name Wei, Gonghong
Organisation OY
Project title
Charting gene regulatory networks for interpreting risk SNPs in prostate cancer
Decision No. 279760
Decision date 14.05.2014
Funding period 01.09.2014 - 31.08.2019
Funding 434 485
WebFOCUS Report
Project description
Three billion base pairs in the human genome are nearly identical (~99.9%) between any two individuals. Nevertheless, genome sequence variation such as single nucleotide polymorphism (SNP) does occur in the population, and may have profound effects on an individual's risk of developing various diseases, including prostate cancer. How human genomic variants cause disease and its progression is in general one of the most compelling puzzles and questions in medicine. The project based at University of Oulu have discovered novel genes and mechanisms that can explain how several genomic variant influences prostate cancer risk and aggressiveness. These findings also suggest ways to improve risk stratification and clinical treatment for prostate cancer. The study also developed the methods namely SNPs-seq to measure the interactions of thousands of SNPs with DNA-associated proteins. The results published in the prestigious journals such as Cell, Nature Genetics, and Nature Communications.