Academy of Finland
Funding decision
Name Jääskeläinen, Erika
Organisation OY
Project title
Exploring longitudinal course and outcomes in schizophrenia at 20-year interval - the Northern Finland Birth Cohorts 1966 and 1986
Decision No. 278286
Decision date 04.06.2014
Funding period 01.09.2014 - 30.06.2018
Funding 145 846
WebFOCUS Report
Project description
The aim of this project was to explore the longitudinal course and prognosis of schizophrenia. This study utilised mainly the Northern Finland 1966 Birth Cohort. During this project we have found that outcome of schizophrenia in middle age, around the age of 43-45 years is not very good: only 11% were employed, and under 20% were in remission. Earlier age of illness onset, longer duration of untreated psychosis, brain morphological changes and poorer cognition, and higher lifetime doses of antipsychotics associated to poor outcomes. Some prognostic factors could be affected by means of early interventions, for example, duration of untreated psychosis. We have also found that high doses of antipsychotics in long-term use associate to poorer functional outcomes, cognitive decline and brain volume changes in schizophrenia. Though residual confounding is still possible, these results suggest that high-dose long-term antipsychotic treatment may have some undesirable effects.