Academy of Finland
Funding decision
Name Ruskamo, Salla
Organisation OY
Project title
Structure and organization of myelin-specific integral membrane proteins
Decision No. 275225
Decision date 10.04.2014
Funding period 01.09.2014 - 31.05.2018
Funding 250 373
WebFOCUS Report
Project description
Myelin insulates axons in the central and peripheral nervous system of all vertebrates enabling the fast transduction of nerve impulses. This project focused on the most abundant integral membrane protein of the central nervous system myelin; proteolipid protein and its shorter variant DM20. The aim was to study the 3D structures and interactions of these proteins as well as their organization and function on multilayered myelin –like membrane assemblies. The results clarify their role in myelin formation and maintenance, as well as the molecular mechanisms behind the demyelinating diseases.