Academy of Finland
Funding decision
Name Lloyd Spetz, Anita
Organisation OY
Project title
CMOS based cell clinic for evalutaion of toxic effect of nanoparticles (ClintoxNP)
Decision No. 268944
Decision date 10.06.2013
Funding period 01.09.2013 - 31.08.2017
Funding 334 616
WebFOCUS Report
Project description
Animal testing is a traditional method to evaluate health effects of chemicals, but expensive, possess ethical issues and results may not be valid for humans. In-vitro evaluations are typically based on ratio of dead and viable cells after exposure and require markers. Currently, the toxic effect of nanoparticles on humans is of large concern. In this project we developed an electronic, marker free, microchip based method (the cell clinic) to evaluate health status of cells after exposure to substances. Healthy cells are flat and star-like, dead cells ball-up, and this change in shape induces change in sensor chip signal. We found that electronics packaging based on ceramics is reliable, biocompatible and allows various functionalities in the cell clinic, like microfluidic system and other sensors. This is a basis for a fully electronic cell health status monitoring device applied in evaluation of toxic effects of nanoparticle on cells, and with potential use for drug testing.