Academy of Finland
Funding decision
Name Saarakkala, Simo
Organisation OY
Project title
Establishment of 3D histopathological grading of osteoarthritis
Decision No. 268378
Decision date 08.05.2013
Funding period 01.09.2013 - 31.08.2018
Funding 425 005
WebFOCUS Report
Project description
The primary objective of this project was to develop 3D histopathological grading method for osteoarthritis (OA) using micro-CT technologies in vitro. We were the first to report that it is possible to reliably image micro-level structure and composition of articular cartilage and subchondral bone in 3D with micro-CT using contrast enhancement for cartilage. We also found that micro-level 3D structure and composition of human osteochondral tissues changes along with osteoarthritis progression. Importantly, we were the first research group in the world to establish a comprehensive, semi-quantitative 3D histopathological grading system for human osteochondral samples using PTA-enhanced micro-CT. Furthermore, we created machine learning based algorithm and pipeline to automatically conduct 3D histopathological grading of osteochondral samples. The algorithm and pipeline are fully open access and freely available to anyone: