Academy of Finland
Funding decision
Name Ruskoaho, Heikki
Organisation HY
Project title
Targeting transcription factor GATA4 in myocardial remodeling and repair
Decision No. 266661
Decision date 17.04.2013
Funding period 01.09.2013 - 31.08.2017
Funding 439 623
WebFOCUS Report
Project description
Heart failure is one of the most serious challenges for modern cardiovascular medicine. The key pathophysiological process that ultimately leads to heart failure is myocardial remodelling, commonly caused by myocardial infarction or hypertension. Despite optimal treatment with existing drugs, the prognosis of patients with heart failure is poor, and novel therapeutic strategies are needed. In this project, we have identified small molecules that inhibit the GATA4-NKX2-5 transcriptional synergy and promote myocardial repair after myocardial infarction and other cardiac injuries. We have also developed nanoparticles that selectively interact with their target receptors in cardiac cells and show predominant accumulation into the endocardial region of the injured heart.