Academy of Finland
Funding decision
 
Name Kaprio, Jaakko
Organisation HY
Project title
Genomic epidemiology of addictions and their consequences - national, Nordic and international dimensions.
Decision No. 263278
Decision date 11.06.2012
Funding period 01.01.2013 - 31.12.2017
Funding 647 412
WebFOCUS Report
Project description
Though smoking has become rarer in Finland, almost every fifth adult Finn continues to smoke. .I have led a series of studies on the genomic epidemiology of smoking and nicotine dependence, based on analyses of smoking behaviour, nicotine dependence and consequent health outcomes, primarily in the Finnish Twin Cohort (the FinnTwin12 study, older cohort and , the Finnish Family Study of Nicotine Dependence) and national cohorts We have found genetic associations increasing the susceptibility to develop nicotine dependence (as measured by interviews and biomarkers), genes related to smoking cessation, smoking persistence and nicotine metabolism . Recent large gwas studies also demonstrate that there are pleiotropic effects of smoking, in particular with psychiatric conditions. Our epigenetic analyses in Finnish and international data sets have complemented the genetic analyses to identify more of the complex biology of smoking behaviour.