Academy of Finland
Funding decision
Name Karppinen, Jaro
Organisation TTL
Project title
Genetic and environmental factors in the etiology of low back disorders
Decision No. 121620
Decision date 13.09.2007
Funding period 01.01.2008 - 31.08.2012
Funding 240 000
WebFOCUS Report
Project description
We evaluated the role of environmental (=non-genetic) factors and genetic variations in low back disorders. Of non-genetic factors, sleep problems, smoking, physical workload factors and obesity increased the incidence of low back pain. Psychosocial factors were related more with multisite pain but they were implicated also in low back pain. Of the genetic variations, especially variations in the interleukin-6 gene were associated with lumbar disc degeneration. In the near future, we will evaluate genetic factors within the context of the whole genome. Afer this, we can continue towards evaluation of interactions between non-genetic and genetic factors.